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PAPA NONOate
CAS No. 146672-58-4
PAPA NONOate( —— )
Catalog No. M36582 CAS No. 146672-58-4
PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePAPA NONOate
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NoteResearch use only, not for human use.
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Brief DescriptionPAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.
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DescriptionPAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.
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In VitroPAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3.
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In VivoPAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound.Animal Model:Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound Dosage:100 μM Administration:Wounds received 100 μM PAPA NONOate in phosphate buffer Result:Increased the wound healing rate in test group.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorEndogenous Metabolite | NO Synthase
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Research Area——
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Indication——
Chemical Information
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CAS Number146672-58-4
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Formula Weight176.22
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Molecular FormulaC6H16N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 50 mg/mL (283.74 mM; Ultrasonic (<60°C)
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SMILESO=NN(O)N(CCC)CCCN
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. R?ssig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274(11):6823-6.?
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